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OpenRouter, LiteLLM, Portkey, or Direct API: How to Pick the Right LLM Gateway

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Developers building LLM-powered apps often compare gateways like OpenRouter, LiteLLM, and Portkey by feature lists, but the more useful question is which operational problem each tool actually solves. OpenRouter suits teams still exploring multiple model families through a single endpoint, while LiteLLM fits infrastructure teams that want self-hosted, deeply configurable proxy control. Portkey targets larger organizations needing governance, guardrails, and observability across many teams and applications. Direct provider APIs remain a strong choice when only one or two vendors are involved and routing complexity is unnecessary. A newer entrant, TackleKey, positions itself as a managed OpenAI-compatible workspace focused on project-level cost visibility and simplicity for smaller development teams.

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