GeneSign Agent Screens DNA Sequences for Biosecurity Threats Before Physical Synthesis

A developer has submitted GeneSign to the Sanity Challenge, an autonomous biosecurity agent designed to screen genetic sequences against a structured knowledge base before physical DNA fabrication occurs. The system queries a Sanity-hosted Content Lake using GROQ to retrieve pathogen taxonomies, biosafety classifications, and CDC-regulated sequence motifs, enabling context-aware threat assessment beyond simple keyword matching. NVIDIA Nemotron, a large language model, generates compliance rationales and can trigger automated interlocks if a sequence is flagged as high-risk. If a sequence clears screening, GeneSign embeds tamper-resistant Ed25519 cryptographic watermarks into coding sequences using synonymous codons, preserving the original amino acid translation. The open-source project includes a live web application with 3D DNA visualization and a threat ledger, with its codebase publicly available on GitHub.