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cryoval: Open-Source CPU-Only Validator Launches for Cryo-EM and ET Maps

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Developer Pedro Sordo Martinez has released cryoval, a free, open-source validation tool for cryo-EM and cryo-ET maps, addressing a gap identified as of July 11, 2026, where no such tool existed on GitHub. The software audits reconstructed maps for overfitting, particle-picking bias, and local noise hallucination without invoking any external reconstruction software. It applies four rules, including cross-validation via FSC thresholds and a benchmark correlation check using the POPSICLE standard, though one rule remains experimental and requires further validation against real EMDB maps. cryoval is CPU-only, achieves 96% test coverage across 31 tests, and is installable via pip under the AGPL-3.0 license. The tool is compatible with Python 3.11 and above and is hosted publicly on GitHub.

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